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  • The Right Dose

    Although acute toxicity studies in animals are an indispensable prerequisite for the ­realisation of clinical trials in humans, these can only be projected to humans to a limited extent, and thus are scientifically problematic and ethically questionable. Therefore, the international regulatory authorities increasingly recommend the use of alternative in vitro methods in the framework of safety studies in accordance with the ”3R Principle“ (Replacement, Reduction, Refinement). more

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