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• Synthetic enzymes could help ID proteins

  Using a rare metal that's not utilized by nature, Rice University chemists have created a synthetic enzyme that could help unlock the identities of thousands of difficult-to-study proteins, including many that play key roles in cancer and other diseases. The research was published online in the Jou more

• Scientists Create a New Way to Study T Cell Signaling

  An experiment that began as a "fantasy pipe dream" just three years ago is now a reality. Researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley, combining nanotechnology with biochemistry, have created unique synthetic membranes that, more

• EpiCept Corporation and Maxim Pharmaceuticals Agree to Merge

  EpiCept Corporation (EpiCept), a privately held corporation, and Maxim Pharmaceuticals, Inc. announced that they have entered into a definitive merger agreement. The transaction is anticipated to close during the fourth quarter of this year and is subject to satisfaction of certain customary closing more

Publications Apoptosis

• Structural and functional interactions of the prostate cancer suppressor protein NKX3.1 with topoisomerase I

  NKX3.1 (NK3 homeobox 1) is a prostate tumour suppressor protein with a number of activities that are critical for its role in tumour suppression. NKX3.1 mediates the cellular response to DNA damage by interacting with ATM (ataxia telangiectasia mutated) and by activation of topoisomerase I. In the more

• Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin

  Publication date: July 2013 Source:European Journal of Medicinal Chemistry, Volume 65 Author(s): Tatiana A. Dias , Cecília L. Duarte , Cristovao F. Lima , M. Fernanda Proença , Cristina Pereira-Wilson A series of chalcone and flavonol derivatives were synthesized in good yield by an eco-f more

• Resonance versus linear responses to alternating electric fields induce mechanistically distinct mammalian cell death

  Publication date: Available online 13 June 2013 Source:Bioelectrochemistry Author(s): Jin Liang , Alex Wing-kee Mok , Yanting Zhu , Jue Shi Alternating electric (AC) fields are known to activate tumor cell death, but the underlying cellular mechanisms are poorly understood. We thus combine more

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