Cytotoxicity

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• Going Live With Click Chemistry: Berkeley Researchers Create a Copper-free Version of the Technique

  Click chemistry, one of the most exciting and proficient new techniques for labeling biomolecules in vitro, has now been extended to studies in the context of live cells as well. This breakthrough opens the door for applications to live cell imaging of numerous biomolecules, including glycans, prote more

• New Methods for Screening Nanoparticles

  Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have developed a screening method to examine how newly made nanoparticles interact with human cells following exposure for various times and doses. This has led to the visualization of how human cells interact with some spe more

Publications Cytotoxicity

• Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids

  Designed and synthesized porphyrin-globotriose hybrids effectively degraded verotoxin-1, which causes severe bloody diarrhoea and fetal hemolytic uremic syndrome (HUS). Degradation was achieved using long-wavelength UV or visible light irradiation in the absence of any additives and under neutral co more

• Disruption of the Dynamics of Microtubules and Selective Inhibition of Glioblastoma Cells by Nanofibers of Small Hydrophobic Molecules

  Ganging up against the bad guys: Nanofibers of 1 efficiently inhibited the growth of glioblastoma cells but exhibited little acute toxicity toward a neuronal cell line. The selective cytotoxicity probably stems from the Warburg effect of cancer cells and the existence of microtubule‐stabilizing p more

• Five New Steroidal Alkaloid Glycosides from Solanum tuberosum

  Abstract Five new steroidal alkaloid glycosides, 1–5, along with the known analog 6, have been isolated from the aerial parts of Solanum tuberosum. The structures of the new compounds were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR and HR‐ESI‐MS techniques, as well as by compa more

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