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Amphiphile (from the Greek αμφις, amphis: both and φιλíα, philia: love, friendship) is a term describing a chemical compound possessing both hydrophilic and hydrophobic properties. Such a compound is called amphiphilic or amphipathic. This forms the basis for a number of areas of research in chemistry and biochemistry, notably that of lipid polymorphism. Organic compounds containing hydrophilic groups at both ends of a prolate molecule are called bolaamphiphile
Structure and Properties
Often, amphiphilic species have several hydrophobic parts, several hydrophilic parts, or several of both. Proteins and some block copolymers are such examples.
Molecules of amphiphilic compounds have hydrophobic (usually of hydrocarbon nature) and hydrophilic (represented by either ionic or uncharged polar functional groups) structural regions.
When placed in an immiscible biphasic system consisting of aqueous and hydrophobic solvent the amphiphilic compound will partition the two phases. The balance between hydrophobic and hydrophilic natures defines the extent of partitioning.
Phospholipids, a class of amphiphilic molecules, are the main components of biological membranes. The amphiphilic nature of these molecules defines the way in which they form membranes. They arrange themselves into bilayers, by positioning their polar groups towards the surrounding aqueous medium, and their hydrophobic chains towards the inside of the bilayer, defining a non-polar region between two polar ones.
Although phospholipids are principal constituents of biological membranes, there are other amphiphilic molecules, such as cholesterol and glycolipids, which are also included in these structures and give them different physical and biological properties.
Many other amphiphilic compounds strongly interact with biological membranes by insertion of hydrophobic part into the lipid membrane, while exposing the hydrophilic part to the aqueous medium, altering their physical behaviour and sometimes disrupting them.
Examples of amphiphiles
There are several examples of molecules that present amphiphilic properties:
Surfactants are an example group of amphiphilic compounds. Their polar region can be either ionic, or non-ionic. Some typical members of this group are: sodium dodecyl sulphate (anionic), Benzalkonium chloride (cationic), Cocamidopropyl betaine (zwitterionic) and octanol (long chain alcohol, non-ionic).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Amphiphile". A list of authors is available in Wikipedia.|