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Aniracetam

Aniracetam

IUPAC name	1-[(4-methoxybenzoyl)]- 2-pyrrolidinone
Identifiers
CAS number	72432-10-1
PubChem	2196
SMILES	COC1=CC=C(C=C1)C(=O)N2CCCC2=O
Properties
Molecular formula	C₁₂H₁₃NO₃
Molar mass	219.237
Pharmacology
Bioavailability	~100%
Routes of administration	Oral and parenteral
Elimination half-life	4 - 5 hr
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Aniracetam (Draganon®, Sarpul®, Ampamet®) is a nootropic drug of the racetam family purported to be considerably more potent than piracetam. It is lipid soluble and has possible cognition enhancing effects. It has been tested in animals extensively, Alzheimer's patients and temporarily-impaired healthy subjects, but has not been tested in healthy, unimpaired humans. It has shown potential as an anxiolytic in three clinical animal models.

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Pharmacology

After a confirmed test of the anxiolytic efficacy in a mouse model, receptor antagonists haloperidol, mecamylamine, and ketanserin were applied. Haloperidol completely reversed the anxiolytic effects, and mecamylamine and ketanserin nearly completely reversed the effects. This shows that aniracetam's anxiolytic mechanism is facilitated by D2/D3 dopamine, nicotinic acetylcholine, and 5-HT2A receptors^[1].

References

^ Nakamura K; Kurasawa M (May 2001). "Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.". Eur J Pharmacol. (Kanagawa, Japan). 420 (1): 33-43. PMID 11412837.

v • d • e Racetams
Aniracetam • Brivaracetam • Coluracetam • Etiracetam • Fasoracetam • Levetiracetam • Nebracetam • Nefiracetam • Oxiracetam • Phenylpiracetam • Piracetam • Pramiracetam • Rolziracetam • Seletracetam

v • d • e Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics (N06B)
Centrally acting sympathomimetics	Amphetamine - Amphetaminil - Atomoxetine - Dexamphetamine - Dextromethamphetamine - Fencamfamin - Fenozolone - Fenetylline - Methylphenidate - Mesocarb - Pemoline - Pipradrol - Prolintane
Xanthine derivatives	Caffeine - Propentofylline
Racetams	Aniracetam - Oxiracetam - Piracetam - Pramiracetam
Eugeroics	Adrafinil - Modafinil
Other psychostimulants and nootropics	Acetylcarnitine - Citicoline - Cyprodenate - Idebenone - Deanol - Dimebon - Fipexide - Linopirdine - Meclofenoxate - Nizofenone - Pirisudanol - Pyritinol - Sulbutiamine - Vinpocetine