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Benfluorex


Benfluorex
Systematic (IUPAC) name
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino] ethyl benzoate
Identifiers
CAS number	23602-78-0
ATC code	C10AX04
PubChem	2318
Chemical data
Formula	C₁₉H₂₀F₃N O₂
Mol. mass	351.363 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Benfluorex is an anorectic and hypolipidemic agent. Clinical studies have shown it may improve glycemic control and decrease insulin resistance in people with poorly controlled type 2 diabetes;^[1]^[2] it is marketed in France as an adjuvant antidiabetic.

Benfluorex is structurally related to fenfluramine.

References

^ Moulin P, Andre M, Alawi H, et al (2006). "Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18-week, randomized, double-blind study". Diabetes Care 29 (3): 515–20. PMID 16505498. Free full text
^ Roger P, Auclair J, Drain P (1999). "Addition of benfluorex to biguanide improves glycemic control in obese non-insulin-dependent diabetes: a double-blind study versus placebo". J Diabetes Complications 13 (2): 62–7. PMID 10432168.

v • d • e Lipid modifying agents (C10)
Statins	Atorvastatin • Cerivastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Simvastatin
Fibrates	Clofibrate • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride
Bile acid sequestrants	Colestyramine • Colestipol • Colextran • Colesevelam
Niacin and derivatives	Niceritrol • Niacin • Nicofuranose • Aluminium nicotinate • Nicotinyl alcohol • Acipimox
Other	Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Ezetimibe