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Brodimoprim


Brodimoprim
Systematic (IUPAC) name
5-[(4-bromo-3,5-dimethoxyphenyl)methyl] pyrimidine-2,4-diamine
Identifiers
CAS number	?
ATC code	J01EA02
PubChem	68760
Chemical data
Formula	C₁₃H₁₅Br N₄O₂
Mol. mass	339.188 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Brodimoprim is a structural derivative of trimethoprim. In brodimoprim, the 4-methoxy group of trimethoprim is replaced with a bromine atom.

As trimethoprim, brodimoprim is a selective inhibitor of bacterial dihydrofolate reductase.^[1]

References

^ Thomson CJ (1993). "Trimethoprim and brodimoprim resistance of gram-positive and gram-negative bacteria". J Chemother 5 (6): 45864. PMID 8195838.

v • d • e Antibacterials for systemic use: sulfonamides (sulfa drugs) and trimethoprim (J01E)
Trimethoprim and derivatives	Trimethoprim • Brodimoprim
Short-acting sulfonamides	Sulfaisodimidine • Sulfamethizole • Sulfadimidine • Sulfapyridine • Sulfafurazole • Sulfanilamide • Sulfathiazole • Sulfathiourea
Intermediate-acting sulfonamides	Sulfamethoxazole • Sulfadiazine • Sulfamoxole
Long-acting sulfonamides	Sulfadimethoxine • Sulfalene • Sulfametomidine • Sulfametoxydiazine • Sulfamethoxypyridazine • Sulfaperin • Sulfamerazine • Sulfaphenazole • Sulfamazon
Combinations	Sulfamethoxazole and trimethoprim
Other	Mafenide • Prontosil • Sulfacetamide • Sulfasalazine • Sulfisoxazole