| Integrin, alpha 1
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| PDB rendering based on 1ck4.
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| Available structures: 1ck4, 1mhp, 1pt6, 1qc5, 1qcy, 2b2x
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| Identifiers
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| Symbol(s)
| ITGA1; CD49a; VLA1
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| External IDs
| OMIM: 192968 MGI: 96599 Homologene: 57137
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| Gene Ontology
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| Molecular Function:
| • magnesium ion binding
• receptor activity
• calcium ion binding
• collagen binding
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| Cellular Component:
| • integrin complex
• membrane
• integral to membrane
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| Biological Process:
| • cell adhesion
• cell-matrix adhesion
• integrin-mediated signaling pathway
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| Orthologs
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| Human
| Mouse
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| Entrez
| 3672
| 109700
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| Ensembl
| na
| ENSMUSG00000042284
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| Uniprot
| na
| Q05DI0
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| Refseq
| NM_181501 (mRNA)
NP_852478 (protein)
| NM_001033228 (mRNA)
NP_001028400 (protein)
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| Location
| na
| Chr 13: 116.08 - 116.22 Mb
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| Pubmed search
| [1]
| [2]
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Additional recommended knowledge
CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.[1]
References
- ^ Entrez Gene: ITGA1 integrin, alpha 1.
Further reading
- Virtanen I, Korhonen M, Kariniemi AL, et al. (1991). "Integrins in human cells and tumors.". Cell Differ. Dev. 32 (3): 215-27. PMID 2099238.
- Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis.". Atherosclerosis 166 (1): 1-11. PMID 12482545.
- Clover J, Dodds RA, Gowen M (1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture.". J. Cell. Sci. 103 ( Pt 1): 267-71. PMID 1429908.
- Bodary SC, McLean JW (1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.". J. Biol. Chem. 265 (11): 5938-41. PMID 1690718.
- Sonnenberg A, Linders CJ, Modderman PW, et al. (1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.". J. Cell Biol. 110 (6): 2145-55. PMID 1693624.
- Belkin VM, Belkin AM, Dol'nikova AE, et al. (1992). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia 56 (12): 2198-206. PMID 1807406.
- Bank I, Roth D, Book M, et al. (1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases.". J. Clin. Immunol. 11 (1): 29-38. PMID 1827128.
- Tabibzadeh S (1990). "Evidence of T-cell activation and potential cytokine action in human endometrium.". J. Clin. Endocrinol. Metab. 71 (3): 645-9. PMID 2144294.
- Tawil NJ, Houde M, Blacher R, et al. (1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells.". Biochemistry 29 (27): 6540-4. PMID 2169872.
- Belkin VM, Belkin AM, Koteliansky VE (1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development.". J. Cell Biol. 111 (5 Pt 1): 2159-70. PMID 2229189.
- MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine.". J. Clin. Pathol. 43 (4): 313-5. PMID 2341567.
- Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3239-43. PMID 3033641.
- Hemler ME, Huang C, Schwarz L (1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.". J. Biol. Chem. 262 (7): 3300-9. PMID 3546305.
- Kono Y, Yang S, Letarte M, Roberts EA (1996). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system.". Exp. Cell Res. 221 (2): 478-85. doi:10.1006/excr.1995.1399. PMID 7493648.
- Eglinton BA, Roberton DM, Cummins AG (1995). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk.". Immunol. Cell Biol. 72 (4): 306-13. PMID 7806264.
- Salter DM, Godolphin JL, Gourlay MS (1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees.". J. Histochem. Cytochem. 43 (4): 447-57. PMID 7897185.
- Pfaff M, Aumailley M, Specks U, et al. (1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI.". Exp. Cell Res. 206 (1): 167-76. doi:10.1006/excr.1993.1134. PMID 8387021.
- Briesewitz R, Epstein MR, Marcantonio EE (1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit.". J. Biol. Chem. 268 (4): 2989-96. PMID 8428973.
- Langholz O, Röckel D, Mauch C, et al. (1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins.". J. Cell Biol. 131 (6 Pt 2): 1903-15. PMID 8557756.
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