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Caco-2 refers to a cell monolayer absorption model. Cell-based functional assays, such as the Caco-2 drug transport model for assessing intestinal transport, are extremely valuable for screening lead compounds in drug discovery.
The Caco-2 cell line was developed by the Sloan-Kettering Institute for Cancer Research through research conducted by Dr. Jorgen Fogh.
The Caco-2 cell line is widely used with in vitro assays to predict the absorption rate of candidate drug compounds across the intestinal epithelial cell barrier. The assay requires that drug absorption rates be determined 21 days after Caco-2 cell seeding to allow for monolayer formation and cell differentiation.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Caco-2". A list of authors is available in Wikipedia.|