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The Clemmensen reduction is a chemical reaction described as a reduction of ketones (or aldehydes) to alkanes using zinc amalgam and hydrochloric acid. This reaction is named after Erik Christian Clemmensen, an Danish-American chemist.
The substrate must be stable in the strongly acidic conditions of the Clemmensen reduction. Acid sensitive substrates should use the Wolff-Kishner reduction, which utilizes strongly basic conditions. As a result of Clemmensen Reduction, the carbon of the carbonyl group involved is converted from Sp2 hybridisation to Sp3 hybridisation. The oxygen atom is lost in the form of one molecule of water.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Clemmensen_reduction". A list of authors is available in Wikipedia.|