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Co-tenidone

Co-tenidone
Combination of
Atenolol	Beta blocker
Chlortalidone	Thiazide diuretic
Identifiers
CAS number	?
ATC code	?
PubChem	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Oral

Co-tenidone (BAN) is a non-proprietary name used to denote a combination of atenolol and chlortalidone. Co-tenidone is used in the treatment of hypertension. The use of β-blockers in hypertension was downgraded in June 2006 in the United Kingdom to fourth-line as they perform less well than other drugs, and that atenolol, the most frequently used β-blocker, at usual doses carries an unacceptable risk of provoking type 2 diabetes.^[1]

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Formulation

Two strengths of co-amilozide is currently available in the UK:

50 mg atenolol and 12.5 mg chlortalidone , BAN of Co-tenidone 50/12.5
100 mg atenolol and 25 mg chlortalidone , BAN of Co-tenidone 100/25

References

British National Formulary 54 September 2007

v • d • e Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents (including alpha)	centrally acting/antiadrenergics (Clonidine, Guanfacine, Methyldopa, Moxonidine, Rescinnamine, Reserpine, Rilmenidine) • ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) • peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin)
Vasodilators	Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensives	serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)
Low ceiling diuretics	Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine
High ceiling diuretics	Loop diuretic (Bumetanide, Furosemide, Torasemide)
Potassium-sparing diuretics	ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)