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ACTH is available as a synthetic derivative in the form of cosyntropin (synthetic ACTH), tradename Cortrosyn®.
It contains the first 24 amino acids of ACTH but retains full function.
In patients with low cortisol levels or symptoms of adrencortical insufficiency, cosyntropin can be used to diagnose Addison's disease. A failure for serum cortisol levels to increase after administration of cosyntropin makes a diagnosis of primary adrenocortical insufficiency more likely. An increase in cortisol upon administration of cosyntropin rules out the condition.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cosyntropin". A list of authors is available in Wikipedia.|