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Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn, Claramax, Clarinex and Aerius. It is an active metabolite of loratadine, which is also on the market.
Desloratadine is available as film coated tablets, solution and oral suspension.
Mechanism of action
Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Most common side-effects are fatigue, dry mouth, headache, and gastrointestinal disturbances.
Desloratadine vs. loratadine
Desloratidine is the major metabolite of loratadine. There are no head-to-head randomised controlled trials of the two drugs. A survey of patients dissatisfied with loratadine published in August 2003 reported equal or better satisfaction with desloratadine, concluding:
A November 2003 article published in the journal American Family Physician about the safety, tolerability, effectiveness, price, and simplicity of desloratadine concluded the following:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Desloratadine". A list of authors is available in Wikipedia.|