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Diethylcathinone



Diethylcathinone
Systematic (IUPAC) name
2-diethylamino-1-phenyl-propan-1-one
Identifiers
CAS number 90-84-6
ATC code A08AA03
PubChem 7029
Chemical data
Formula C13H19NO 
Mol. mass 205.30
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B

Legal status

Schedule IV(US)

Routes  ?

Diethylcathinone (also called Diethylpropion and Amfepramone), is a sympathomimetic stimulant drug marketed as an appetite suppressant. It is sold under the brand name Tenuate or Tenuate Dospan, and may also be known as Amfepramone. The popular antidepressant, Wellbutrin (bupropion) is an analogue of this chemical. Both diethylpropion and bupropion have a stimulant effect on the CNS.

Additional recommended knowledge

Contents

Pharmacology

  Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. Chemically, it is the N,N-diethyl homologue of cathinone and dimethylcathinone. Diethylpropion is manufactured in 25 mg tablets and 75 mg controlled-release tablets (Tenuate®, Tepanil Ten-Tab®). Diethylpropion is classified as a Schedule IV controlled substance in the United States.

It is also used in the treatment of migraine (off-label).

Contraindications

  • Hypersensitivity to sympathomimetic amines
  • Advanced arteriosclerosis or symptomatic cardiovascular disease
  • Moderate or severe hypertension
  • Hyperthyroidism
  • History of drug abuse
  • MAO inhibitor use (within 14 days)

Side effects

Severe
  • Insomnia
  • Pulmonary hypertension
  • Stroke
  • Psychosis
Cardiovascular
  • Tachycardia, hypertension, arrhythmia, chest pain
Ear, nose, and throat
  • Xerostomia, metallic taste
Endocrine
  • Changes in libido, gynecomastia, menstrual irregularities
Eye
  • Blurred vision
Gastrointestinal
  • Nausea/vomiting, constipation, abdominal cramps
Hematological
  • Bone marrow depression, agranulocytosis, leukopenia
Neurological
  • Tremor
Psychological
  • Euphoria, agitation, nervousness, restlessness, dizziness, anxiety, headache, mental depression, seizures
Skin
  • Rash, hives, alopecia, ecchymosis
Urogenital and reproductive
  • Changes in libido, impotence

See also

References

     
    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Diethylcathinone". A list of authors is available in Wikipedia.
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