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Endothelin receptor antagonist



A endothelin receptor antagonist (ERA) is a drug which blocks endothelin receptors.

Two main kinds of ERAs exist:

  • selective ERA (e.g. sitaxsentan), which affect endothelin A.
  • dual ERAs,(e.g. bosentan) which affect both endothelin A and B .[1]

See also

  • Endothelin receptor

References

  1. ^ http://cvpharmacology.com/vasodilator/ETblockers.htm


v • d • e
Medications used in the management of pulmonary arterial hypertension (B01, C02)
Prostacyclin analoguesBeraprost, Epoprostenol, Iloprost, Treprostinil
Endothelin receptor antagonistsAmbrisentan, Bosentan, Sitaxsentan
PDE5 inhibitorsSildenafil, Tadalafil
Adjunctive therapyCalcium channel blockers, Diuretics, Digoxin, Oxygen therapy, Warfarin
v • d • e
Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents (including alpha)centrally acting/antiadrenergics (Clonidine, Guanfacine, Methyldopa, Moxonidine, Rescinnamine, Reserpine, Rilmenidine) • ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) • peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin)
VasodilatorsDiazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensivesserotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)
Low ceiling diureticsThiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine
High ceiling diureticsLoop diuretic (Bumetanide, Furosemide, Torasemide)
Potassium-sparing diureticsESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Endothelin_receptor_antagonist". A list of authors is available in Wikipedia.
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