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Ethacrynic acid



Ethacrynic acid
Systematic (IUPAC) name
2-[2,3-dichloro-4-(2-methylidenebutanoyl) phenoxy] acetic acid
Identifiers
CAS number 58-54-8
ATC code  ?
PubChem 3278
DrugBank APRD00251
Chemical data
Formula C13H12Cl2O4 
Mol. mass 303.137 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding > 98%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Ethacrynic acid (trade name Edecrin) is a loop diuretic medication used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure. Unlike the other loop diuretics, ethacrynic acid is not a sulfonamide and thus, its use is not contraindicated in those with sulfur allergies. Ethacrynic acid is a phenoxyacetic acid derivative containing a ketone and a methylene group. A cysteine adduct is formed with the methylene group and this is the active form.

Additional recommended knowledge

Administration

25 mg and 50 mg tablets are available for oral use. The sodium salt (ethacrynate sodium) can also be given intravenously.

Side effects

As a diuretic, ethacrynic acid can cause frequent urination, but this usually resolves after taking the drug for a few weeks.

Ethacrynic acid can also cause low potassium levels, which may manifest as muscle cramps or weakness. It has also been known to cause reversible or permanent hearing loss and liver damage. On oral administration, it produces diarrhea; intestinal bleeding may occur at higher doses.

MECHANISM OF ACTION Acts by inhibiting sodim-potassium-chloride cotransport in the ascending loop of Henle. Loss of potassium ions is less marked but chances of hypochloremic alkalosis are greater. The dose response curve of ethacrynic acid is steeper than that of furosemide and, in general, it is less manageable; dose range is 50-150mg.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ethacrynic_acid". A list of authors is available in Wikipedia.
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