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The organic compound ethyl acetoacetate (EAA) is the ethyl ester of acetoacetic acid. It is a solvent, and is used as a chemical intermediate in the production of a wide variety of compounds, such as amino acids, analgesics, antibiotics, antimalarial agents, antipyrene and aminopyrene, and vitamin B1; and also in the manufacture of dyes, inks, lacquers, perfumes, plastics, and yellow paint pigments. Alone, it is used as a flavoring for food.
Another method is to use acetyl ketene and ethanol. They directly form ethyl acetoacetate, and the yield is good, so this method is widely used in industry, but acetyl ketene is very dangerous.
Ethyl acetoacetate is often used similar to diethyl malonate in the Malonic ester synthesis or the Knoevenagel condensation. The protons alpha to carbonyl groups are easily deprotonated and than the carbanion formed can undergo nucleophilic substitution. A subsequent thermal decarboxylation is also possible.
Carey, Francis A. (2006). Organic Chemistry, Sixth Edition, New York, NY: McGraw-Hill. ISBN 0-07-111562-5.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ethyl_acetoacetate". A list of authors is available in Wikipedia.|