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Fenoldopam


Fenoldopam
Systematic (IUPAC) name
8-chloro-2-(4-hydroxyphenyl)- 4-azabicyclo[5.4.0] undeca-7,9,11-triene-9,10-diol
Identifiers
CAS number	67227-57-0
ATC code	C01CA19
PubChem	3341
DrugBank	APRD00969
Chemical data
Formula	C₁₆H₁₆Cl N O₃
Mol. mass	305.756 g/mol
Pharmacokinetic data
Bioavailability	n/a
Metabolism	Hepatic (CYP not involved)
Half life	5 minutes
Excretion	Renal (90%) and fecal (10%)
Therapeutic considerations
Licence data	US
Pregnancy cat.	B(US)
Legal status
Routes	Intravenous

Fenoldopam is a synthetic compound that acts as a selective peripheral dopamine D_1A receptor agonist. Fenoldopam is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation, decreasing afterload and also through specific dopamine receptors along the nephron promoting sodium excretion. Possible adverse effects are hypotension and increase in intraocular pressure.

v • d • e Anti-parkinson drugs: dopaminergic agents (N04B)
Dopa and derivatives	Levodopa, Melevodopa, Etilevodopa
Adamantane derivatives	Amantadine
Dopamine agonists	Apomorphine, Bromocriptine, Cabergoline, Dihydrexidine, Dihydroergocryptine mesylate, Fenoldopam, Lisuride, Pergolide, Piribedil, Pramipexole, Quinpirole, Ropinirole, Rotigotine, SKF 38393, SKF 82958
MAOIs	Selegiline, Rasagiline
Other	Tolcapone, Entacapone, Budipine

v • d • e Cardiac stimulants excluding cardiac glycosides (C01C)
Adrenergic and dopaminergic agents	Etilefrine • Isoprenaline • Norepinephrine • Dopamine • Norfenefrine • Phenylephrine • Dobutamine • Oxedrine • Metaraminol • Methoxamine • Mephentermine • Dimetofrine • Prenalterol • Dopexamine • Gepefrine • Ibopamine • Midodrine • Octopamine • Fenoldopam • Cafedrine • Arbutamine • Theodrenaline • Epinephrine
Phosphodiesterase inhibitors (PDE3I)	Amrinone • Milrinone • Enoximone • Bucladesine
Other cardiac stimulants	Angiotensinamide • Xamoterol • Levosimendan