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GDP-fucose protein O-fucosyltransferase 2
protein O-fucosyltransferase 2
Chr. 21 q22.3
GDP-fucose protein (POFUT2) is an O-fucosyltransferase 2 enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats. The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α- O-serine/threonine.
Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related
enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.
Transferases: glycosyltransferases ( EC 2.4) 2.4.1 - Hexosyltransferases: glucosyltransferase Phosphorylase (Starch, Glycogen, Myo-) - Glycogen synthase - Debranching enzyme - Branching enzyme - 1,3-beta-glucan synthase - Ceramide glucosyltransferase 2.4.1 - Hexosyltransferases: other Galactosyltransferase (Lactose synthase, B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase) - Glucuronosyltransferase ( UGT1A1, UGT2B7, Hyaluronan synthase) - Fucosyltransferase ( POFUT1, POFUT2) 2.4.2 - Pentosyltransferases: ADP ribose Cholera toxin - Diphtheria toxin - Pertussis toxin - Poly ADP ribose polymerase 2.4.2 - Pentosyltransferases: other Purine nucleoside phosphorylase - Adenine phosphoribosyltransferase - Hypoxanthine-guanine phosphoribosyltransferase - Uracil phosphoribosyltransferase - Amidophosphoribosyltransferase
This article is licensed under the
GNU Free Documentation License. It uses material from the Wikipedia article "GDP-fucose_protein_O-fucosyltransferase_2". A list of authors is available in Wikipedia.
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