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Interleukin 11 (IL-11) is a cytokine (first isolated in 1990) that originates from bone marrow stroma and activates B cells and megakaryocytes. It is also known under the names Adipogenesis inhibitory factor (AGIF) and Oprelvekin.
Compared to other interleukins, IL-11 relatively under-characterized.
IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. Besides from lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many tissues such as brain, gut and testis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Interleukin_11". A list of authors is available in Wikipedia.|