Interleukin-22 (IL-22) is a cytokine with homology to IL-10 that was originally called IL-10-related T cell-derived inducible factor (IL-TIF). Human IL-TIF activates the transcription factors stat-1 and stat-3 in several hepatoma cell lines and up-regulates production of acute phase proteins such as serum amyloid A, 1-antichymotrypsin and haptoglobin in HepG2 human hepatoma cells. IL-22, signals through the interferon receptor-related proteins CRF2-4 and IL-22R.
^ Dumoutier L., Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc. Natl. Acad. Sci. U.S.A. 2000, Volume 97 pages 10144-10149.
^ Xie et al., Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R, Journal of Biological Chemistry, 2000, Volume 275, page 31335-31339.