PFPP

Template:DISPLAYTITLE:pFPP

PFPP
Systematic (IUPAC) name
1-(4-fluorophenyl)piperazine
Identifiers
CAS number	2252-63-3
ATC code	?
PubChem	75260
Chemical data
Formula	C10H13FN2
Mol. mass	180.222 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic
Half life	6-8 hours
Excretion	renal
Therapeutic considerations
Pregnancy cat.	Additional recommended knowledge How to quickly check pipettes? Recognize and detect the effects of electrostatic charges on your balance How to ensure accurate weighing results every day? ?
Legal status
Routes	oral

Parafluorophenylpiperazine (flippiperazine, fluoperazine, pFPP, 4-FPP) is a piperazine derivative with mildly hallucinogenic and euphoric effects^[1][2] which has been sold as an ingredient in legal recreational drugs known as "Party pills", initially in New Zealand and subsequently in other countries around the world.

pFPP has been found in vitro to act mainly as a 5HT_1A serotonin receptor agonist, with some affinity for 5HT_2A and 5HT_2C receptors. It also inhibits the reuptake of serotonin and norepinephrine. pFPP was originally discovered as a metabolite of the hypnotic antihistamine Niaprazine in 1982^[3], but was subsequently re-discovered in 2003 as a potential recreational drug, and subsequently sold as an ingredient in "Party pills" in New Zealand, under brand names such as "The Big Grin","Mashed" and "Extreme Beans".

pFPP has little stimulant effects, with its subjective effects derived mainly from its action as a 5HT_1A agonist ^[4]. Its effects have been described as similar to a cross between Fluoxetine and a very small dose of LSD^{[citation needed]}, both of which have significant actions as 5HT_1A agonists in addition to their primary mechanism of action. pFPP is active at doses between 20mg - 150mg, but higher doses cause a range of side effects including migraine headaches, muscle aches, anxiety, nausea and vomiting.

See also

• BZP
• MBZP
• mCPP
• MeOPP
• TFMPP
• MDBZP
• 2C-B-BZP
• DBZP
• Party pills
• Piperazine

References