Phenylethanolamine N-methyltransferase

phenylethanolamine N-methyltransferase
Identifiers
Symbol	PNMT
Alt. Symbols	PENT
Entrez	5409
HUGO	9160
OMIM	171190
RefSeq	NM_002686
UniProt	P11086
Other data
EC number	2.1.1.28
Locus	Chr. 17 q21-q22

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts Norepinephrine (Noradrenalin) to Epinephrine (Adrenalin).

PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.

v • d • e Transferase: one carbon transferases (EC 2.1)
2.1.1 - Methyltransferases	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Betaine-homocysteine methyltransferase - Catechol-O-methyl transferase - Histamine N-methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase - Phosphatidyl ethanolamine methyltransferase - Phenylethanolamine N-methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - Tryptamine N-methyltransferase - DNA methyltransferase
2.1.2 - Hydroxy methyl-, Formyl- and Related Transferases	Serine hydroxymethyltransferase - Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase - Aminomethyltransferase
2.1.3 - Carboxy- and Carbamoyl transferases	Ornithine transcarbamylase
2.1.4 - Amidino transferases	Arginine:glycine amidinotransferase

v • d • e Amino acid metabolism enzymes
phenylalanine→tyrosine→fumarate→TCA	Phenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase
tyrosine→dopamine→epinephrine	Tyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase
leucine→HMG-CoA (keto)	Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase
isoleucine/valine→propionyl-CoA	Branched-chain alpha-keto acid dehydrogenase complex
methionine→cysteine→propionyl-CoA	Methionine adenosyltransferase - Adenosylhomocysteinase - (or MTR) - Cystathionine beta synthase - Cystathionine gamma-lyase
propionyl-CoA→succinyl-CoA→TCA	Propionyl-CoA carboxylase - Methylmalonyl-CoA mutase
serine→glycine	Serine hydroxymethyltransferase
histidine	to histamine: Histidine decarboxylase - to glutamate: Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase
tryptophan→serotonin→melatonin	Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - 5-hydroxyindole-O-methyltransferase
asparagine→aspartate→oxaloacetate→TCA	Asparaginase/Asparagine synthetase - Aspartate transaminase
glutamate	Glutaminase - Glutamate decarboxylase
lysine→keto	Saccharopine dehydrogenase
other	Tyrosinase

Category: EC 2.1.1

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Phenylethanolamine_N-methyltransferase". A list of authors is available in Wikipedia.

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