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The Reimer-Tiemann reaction is a chemical reaction used for the ortho-formylation of phenols.
Chloroform (1) reacts with strong base to form the chloroform carbanion (2), which will quickly alpha-eliminate to give dichlorocarbene (3). Dichlorocarbene will react in the ortho- and para- position of the phenate (5) to give the dichloromethyl substituted phenol (7). After basic hydrolysis, the desired product (9) is formed.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Reimer-Tiemann_reaction". A list of authors is available in Wikipedia.|