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Roflumilast



Roflumilast
Systematic (IUPAC) name
 ?
Identifiers
CAS number  ?
ATC code R03DX07
PubChem 449193
DrugBank EXPT02802
Chemical data
Formula C17H14Cl2F2N2O3 
Mol. mass 403.212 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system.

Karish SB, Gagnon JM. Ann Pharmacother. 2006 May 30


Roflumilast(3-cyclopropylmethoxy-4 difluromethoxy-n-[3,5-dicloropyrid-4yl]-benzamide) is a selective pde4 inhibitor developed by altana pharma.Inhibition of pde4 theoretically leads to inhibition of proinflammatory mediators and the clinical effects of inhibition of bronchoconstriction,chemotaxis,and inflammation

Prashant R. Shirode Mumbai( INDIA )

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Roflumilast". A list of authors is available in Wikipedia.
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