• plasma membrane • integral to plasma membrane • phagocytic vesicle
• inflammatory response • signal transduction • activation of NF-kappaB-inducing kinase • macrophage activation • detection of triacylated bacterial lipoprotein • positive regulation of tumor necrosis factor biosynthetic process • innate immune response • positive regulation of interleukin-6 biosynthetic process
RNA expression pattern
More reference expression data
XM_001129777 (mRNA) XP_001129777 (protein)
NM_030682 (mRNA) NP_109607 (protein)
Chr 4: 38.47 - 38.48 Mb
Chr 5: 65.2 - 65.21 Mb
TLR 1 is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.