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Thiothixene


Thiothixene
Systematic (IUPAC) name
(Z)-N,N-dimethyl-9- [3-(4-methylpiperazin-1-yl)propylidene]- thioxanthene-2-sulfonamide
Identifiers
CAS number	5591-45-7
ATC code	N05AF04
PubChem	5454
DrugBank	none
Chemical data
Formula	C₂₃H₂₉N₃O₂S₂
Mol. mass	443.627
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	10-20 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	?
Routes	oral

Thiothixene (sold as Navane) is a thioxanthene drug used as a typical antipsychotic medication. It is a thioxanthene derivative and is the cis isomer of N,Ndimethyl- 9-[3-(4-methyl-1-piperazinyl)-propylidene] thioxanthene-2-sulfonamide.

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Although widely used in the treatment of schizophrenia for several decades, thiothixene is seldom used today in favor of atypical antipsychotics such as risperidone.

v • d • e Psycholeptics: antipsychotics (N05A)
Phenothiazine typical antipsychotics	Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine
Other typical antipsychotics	Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol, Trifluperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine)
Atypical antipsychotics	Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)