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Weinreb ketone synthesis
The Weinreb ketone synthesis is a chemical reaction used to transform N,O-dimethylhydroxamic acids (Weinreb amides, 1) into ketones (3).
Addition of the organometallic nucleophile to the Weinreb amide produces a stable tetrahedral chelate (2), which upon hydrolysis produces the desired ketone.
Weinreb amides are synthesized typically from their corresponding carboxylic acids.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Weinreb_ketone_synthesis". A list of authors is available in Wikipedia.|