Heart Failures

News Heart Failures

• New method for detecting nitroxyl will boost cardiac drug research

  Wake Forest University scientists have developed a new research tool in the pursuit of heart medications based on the compound nitroxyl by identifying unique chemical markers for its presence in biological systems. Nitroxyl, a cousin to the blood-vessel relaxing compound nitric oxide, has been show more

• Bayer Strengthens Research and Development

  The Bayer Group is to further expand its research and development activities despite the current financial and economic crisis. “The task now is to set the right course. Only through innovation can our company generate the growth that is essential to safeguard its sustained success,” said Werner Wen more

• Beckman Coulter to Acquire Biosite Incorporated

  Beckman Coulter, Inc. and Biosite(R) Incorporated announced that they have entered into a definitive merger agreement under which Beckman Coulter will acquire all of Biosite's outstanding common stock in a cash tender offer of $85.00 per share, or approximately $1.55 billion on a fully diluted share more

Publications Heart Failures

• Enhanced Water Dispersibility of Coenzyme Q10 by Complexation with Albumin Hydrolysate

  The biologically important coenzyme Q10 (CoQ10) is widely used as a drug for chronic heart failure, as a nutritional supplement, and in cosmetics. However, the oral bioavailability of CoQ10 is poor due to its extremely low solubility in aqueous media. In this study, complexation of CoQ10 with albumi more

• Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy [Cell Biology]

  Cardiac hypertrophy is a strong predictor of morbidity and mortality in patients with heart failure. Small molecule histone deacetylase (HDAC) inhibitors have been shown to suppress cardiac hypertrophy through mechanisms that remain poorly understood. We report that class I HDACs function as signal- more

• Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain {alpha}-ketoacid dehydrogenase kinase [Biochemistry]

  The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes. BCAA homeostasis is controlled by the mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC), which is negatively regulated by more

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