Immunology

News Immunology

• Elemental bones

  Exposure to chemical pollutants is of growing concern to regulators, health workers, and environmentalist groups alike. Now, researchers in the US and Russia have demonstrated that samples of human bone can act as a biological marker for dozens of metals and toxic elements across the periodic table. more

• Agilent Technologies to present novel methods for sensing nanoscale binding events with atomic force microscope

  Agilent Technologies Inc. announced that Dr. W. Travis Johnson, Life Sciences Applications manager, will present a paper on innovative techniques for using scanning probe microscopes (SPMs) and atomic force microscopes (AFMs) in the study of biological phenomena. Johnson will discuss TREC - Topograp more

• Scientists Create a New Way to Study T Cell Signaling

  An experiment that began as a "fantasy pipe dream" just three years ago is now a reality. Researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley, combining nanotechnology with biochemistry, have created unique synthetic membranes that, more

White papers Immunology

• Sniffing Out the Secrets of Social Behavior
  

  In his novel "Perfume - the Story of a Murderer", Patrick Süskind managed to put the power of odors into words better than anyone before him. It may be a fascinating idea, but no one will ever be able to create the perfect fragrance that makes a person irresistibly attractive. In the animal world, on the other hand, olfactory signals are an essential element of social communication. Yet we are only just beginning to understand the complexities and functional differences of the sense of smell in mammals. Professor Marc Spehr is leading the Department of Chemosensation at RWTH Aachen University since 2009, where he is conducting research on the neuronal mechanisms of olfactory perception and signal processing using the mouse model. In his experiments, he and his team are trying to find out how substances for social interaction are perceived and how this perception generates a specific type of behavior more

Publications Immunology

• [Perspective] Immunology: Crowdsourcing Immunity

  Computational methods reveal the nature and diversity of antibodies in HIV-infected individuals. [Also see Report by Georgiev et al.] more

• IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner [Immunology]

  A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a potent cytokine that can promote organ-specific autoimmunity when up-regulated on tissue cells. Here we report that T cells eradicated 2-wk-old solid tu more

• Mechanism of somatic hypermutation at the WA motif by human DNA polymerase {eta} [Immunology]

  Somatic hypermutation is programmed base substitutions in the variable regions of Ig genes for high-affinity antibody generation. Two motifs, RGYW and WA (R, purine; Y, pyrimidine; W, A or T), have been found to be somatic hypermutation hotspots. Overwhelming evidence suggests that DNA polymerase η more

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