Infectious Disease

News Infectious Disease

• Authorized generics agreements – last ditch effort on part of branded pharma

  As pay-for-delay agreements look to be on the way out of the pharmaceutical industry in Europe and the US, a new report by independent market analyst Datamonitor forecasts that the number of authorized generics (AG) agreements will grow, in tandem with the increasing convergence between branded and more

• New silver nanoparticle skin gel for healing burns

  Scientists in India are reporting successful laboratory tests of a new and potentially safer alternative to silver-based gels applied to the skin of burn patients to treat infections. With names like silver sulfadiazine and silver nitrate, these germ-fighters save lives and speed healing. The resear more

• Zero in on ozone with fluorescent solution that detects harmful molecule in air and body

  Researchers at the University of Pittsburgh have developed a fluorescent substance that glows bright green when exposed to even minute amounts of ozone in the air and in biological samples such as human lung cells. A molecule consisting of three oxygen atoms, ozone is at once a harmful pollutant and more

White papers Infectious Disease

• Sniffing Out the Secrets of Social Behavior
  

  In his novel "Perfume - the Story of a Murderer", Patrick Süskind managed to put the power of odors into words better than anyone before him. It may be a fascinating idea, but no one will ever be able to create the perfect fragrance that makes a person irresistibly attractive. In the animal world, on the other hand, olfactory signals are an essential element of social communication. Yet we are only just beginning to understand the complexities and functional differences of the sense of smell in mammals. Professor Marc Spehr is leading the Department of Chemosensation at RWTH Aachen University since 2009, where he is conducting research on the neuronal mechanisms of olfactory perception and signal processing using the mouse model. In his experiments, he and his team are trying to find out how substances for social interaction are perceived and how this perception generates a specific type of behavior more

• Characterizing Biotherapeutics with HPLC
  

  As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmaceutical to approval at the regulatory agencies. The introduction of the first so-called biosimilars in Europe further increased the demand for highly efficient analysis methods. The continuous development of new stationary phases for the common modes of biochromatography, such as size exclusion, ion exchange and hydrophilic interaction chromatography support biochemists in increasing lab productivity and establishing high-throughput HPLC analysis not only for small molecules but also for large biopolymers more

Publications Infectious Disease

• Radiofluorinated Carbohydrates for Positron Emission Tomography

  Abstract: 2-Deoxy-2-[18F]fluoro-D-glucose (2-18FDG) has represented radiofluorinated carbohydrates as the most successful tracer for positron emission tomography (PET). 2-18FDG uptake depends on glucose metabolism, which is related to a disease progression. 2-18FDG has been widely used in onc more

• 40‐Hz Square‐Wave Stimulation Requires Less Energy to Produce Muscle Contraction: Compared with the TASER® X26 Conducted Energy Weapon

  Abstract Conducted energy weapons (CEWs) (including the Advanced TASER® X26 model produced by TASER International, Inc.) incapacitate individuals by causing muscle contractions. In this study using anesthetized swine, the potential incapacitating effect of primarily monophasic, 19‐Hz voltage imp more

• Membrane Fusion-Competent Virus-Like Proteoliposomes and Proteinaceous Supported Bilayers Made Directly from Cell Plasma Membranes

  Virus-like particles are useful materials for studying virus–host interactions in a safe manner. However, the standard production of pseudovirus based on the vesicular stomatitis virus (VSV) backbone is an intricate procedure that requires trained laboratory personnel. In this work, a new strategy f more

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