Mutations

News Mutations

• Bio Nano Consulting partner develops novel nanolitre scale technique

  Bio Nano Consulting (BNC) announced the availability of a new technique that screens low-yielding proteins, facilitating the evaluation of both protein denaturation and protein:drug interactions. This novel method, pioneered by researchers from the UCL Department of Biochemical Engineering and the more

• Scientists unlock mystery in important photosynthesis step

  An international team of scientists, including two from Arizona State University, have taken a significant step closer to unlocking the secrets of photosynthesis, and possibly to cleaner fuels. Plants and algae, as well as cyanobacteria, use photosynthesis to produce oxygen and "fuels," the latter b more

• Enzyme design with remote effects
  

  Engineers are unlikely to tinker with the cooling system if they want to increase the size of an engine. Yet chemists at the Max Planck Institute for Coal Research have adopted an approach similar to this in their efforts to optimise an enzyme for practical applications. They substituted two amino a more

White papers Mutations

• Application of the Amplifluor® SNPs Genotyping System using a FLUOstar OPTIMA microplate reader
  

  The detection of SNPs (single nucleotide polymorphisms) is an important tool for researchers in order to find mutations in DNA sequences. In this application note we describe a homogeneous fluorescence assay based on PCR. The Amplifluor® SNPs HT Genotyping System from Millipore was used to screen a number of samples with the help of the FLUOstar OPTIMA multidetection microplate reader from BMG LABTECH more

Publications Mutations

• SKP2 High Expression, KIT Exon 11 Deletions, and Gastrointestinal Bleeding as Predictors of Poor Prognosis in Primary Gastrointestinal Stromal Tumors

  by Ang Lv, Zhongwu Li, Xiuyun Tian, Xiaoya Guan, Min Zhao, Bin Dong, Chunyi Hao Background and Aims Considering the indication of adjuvant therapy, the recurrence risk for primary gastrointestinal stromal tumor (GIST) after surgery needs to be accurately estimated. However, current risk stratific more

• Analysis of PTEN Methylation Patterns in Soft Tissue Sarcomas by MassARRAY Spectrometry

  by Liang Yin, Wei-Juan Cai, Chun-Xia Liu, Yun-Zhao Chen, Jian-Ming Hu, Jin-Fang Jiang, Hong-An Li, Xiao-Bin Cui, Xiang-Yun Chang, Wen Jie Zhang, Kan Sun, Feng Li Soft tissue sarcomas (STSs) are a rare and fascinating group of diseases that can be subdivided into specific reciprocal translocations more

• miR-219-5p Inhibits Receptor Tyrosine Kinase Pathway by Targeting EGFR in Glioblastoma

  by Soumya Alige Mahabala Rao, Arivazhagan Arimappamagan, Paritosh Pandey, Vani Santosh, Alangar Sathyaranjandas Hegde, Bangalore Ashwathnarayanara Chandramouli, Kumaravel Somasundaram Glioblastoma is one of the common types of primary brain tumors with a median survival of 12–15 months. The recep more

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