My watch list
my.chemeurope.com  
Login  

Studying bacterial metabolites with mass spectrometry

19-Feb-2013

Organic compounds produced by colonies of bacteria can now be characterised using a mass-spectrometry technique that is both location specific and non-destructive. The method enables the rapid identification of metabolites from specific areas of an agar gel without affecting the viability of the colony.

Nanospray desorption electrospray ionisation (nano-DESI) is coupled to MS/MS and provides excellent sensitivity. The authors of this paper use the technique to study chemical gradients of lipids and metabolites in living colonies of Synechococcus sp. PCC 7002 bacteria, finding several new glycolipids that have not been observed using conventional cell-extraction approaches.

Increased knowledge of how microbial metabolites are produced could lead to the development of new methods for bio-fuel production, drug discovery and clinical research, as well as a better understanding of the dynamic microbial world.

Original publication:

Lanekoff et al, Analyst, 2013

Facts, background information, dossiers
  • metabolites
  • Pacific Northwest N…
More about Pacific Northwest National Laboratory
  • News

    How seashells get their strength

    Seashells and lobster claws are hard to break, but chalk is soft enough to draw on sidewalks. Though all three are made of calcium carbonate crystals, the hard materials include clumps of soft biological matter that make them much stronger. A study reveals how soft clumps get into crystals ... more

    New flow battery offers lower-cost energy storage

    Energy storage system owners could see significant savings from a new flow battery technology that is projected to cost 60 percent less than today's standard flow batteries. The organic aqueous flow battery is expected to cost $180 per kilowatt-hour once the technology is fully developed. T ... more

    Nanomaterial self-assembly imaged in real time

    A team of researchers from UC San Diego, Florida State University and Pacific Northwest National Laboratories has for the first time visualized the growth of 'nanoscale' chemical complexes in real time, demonstrating that processes in liquids at the scale of one-billionth of a meter can be ... more

More about Royal Society of Chemistry
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE