My watch list  

New test for skin sensitization without using animals


In an advance in efforts to reduce the use of animals in testing new cosmetic and other product ingredients for skin allergies, scientists are describing a new, highly accurate non-animal test for these skin-sensitizers. Their study appears in ACS' journal Chemical Research in Toxicology.

Bruno Miguel Neves and colleagues explain that concerns about the ethics and costs of animal-based tests for skin sensitizers, plus regulations in the European Union, are fostering a search for alternative tests. Testing product ingredients prior to marketing is important, because allergic contact dermatitis is the most prevalent form of immunotoxicity in humans.

The scientists describe development of a cell-based alternative test that enlists genes and signaling pathways in mouse skin cells growing in the laboratory. Exposure to skin sensitizers triggers characteristic responses, activating genes and making cells release substances that communicate with adjacent cells. Evaluation of the test on 18 compounds showed that it had a sensitivity of 92 percent in correctly identifying actual sensitizers. It had a specificity of 100 percent and did not produce any false positive results — indicating that a substance caused sensitization when, in fact, it did not. The approach could be "extremely valuable" in revealing the interaction of skin cells with sensitizers, the scientists say.

Facts, background information, dossiers
More about American Chemical Society
  • News

    Dog's nose inspires new gas sensor materials

    It is well known that dogs have a better sense of smell than humans. For years, researchers have been trying to develop an artificial detector that is just as good as a canine's nose. Now, one group reports in ACS Nano that they were able to mimic a dog's sniffer with graphene-based nanoscr ... more

    Printable, colorful camouflage with polymers

    In nature, colors can serve as a form of communication, but they can also hide animals and plants, camouflaging them from sight. Researchers now report that they have developed polymers that can better mimic nature's color-changing abilities than existing polymers. They say the materials co ... more

    Scaling to new heights with gecko-inspired adhesive

    Some animals, such as geckos, can easily climb up walls and across ceilings. But currently, no material exists that allows everyday people to scale walls or transverse ceilings as effortlessly. Now, scientists report a dry adhesive that could someday make it easier to defy gravity. Geckos ... more

  • Videos

    Why is Olive Oil Awesome?

    Whether you sop it up with bread or use it to boost your cooking, olive oil is awesome. But a lot of chemistry goes on in that bottle that can make or break a product. Take the “extra virgin” standard: Chemistry tells us that a higher free-fatty-acid content leads to a lower grade, less tas ... more

    Microbots zoom around water, destroying bacteria

    One day, the tiny robot you see here could help clean up contaminated water. In places where potable sources are scarce, they can destroy disease-causing bacteria in its path and unlike conventional disinfectants, the microbots can be removed easily with a magnet. more

    The chemicals we leave behind

    The products we use every day leave behind chemical footprints. Learn how and why researchers are now studying those trails. Mass spectrometry is helping researchers learn more about our interactions with the everyday chemicals we use, such as DEET, caffeine, even medications. In this episo ... more

  • Events
    22-08 – 26-08
    Boston, US

    262nd ACS National Meeting & Exposition

    The American Chemical Society conference 262nd ACS National Meeting & Exposition will take place in Boston, US from 2021-08-22 to 2021-08-26. more

    21-03 – 25-03
    San Antonio, US

    261st ACS National Meeting & Exposition

    The American Chemical Society conference 261st ACS National Meeting & Exposition will take place in San Antonio, US from 2021-03-21 to 2021-03-25. more

    23-08 – 27-08
    San Francisco, US

    260th ACS National Meeting & Exposition

    The American Chemical Society conference 260th ACS National Meeting & Exposition will take place in San Francisco, US from 2020-08-23 to 2020-08-27. more

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE