My watch list
my.chemeurope.com  
Login  

New test for skin sensitization without using animals

02-Apr-2013

In an advance in efforts to reduce the use of animals in testing new cosmetic and other product ingredients for skin allergies, scientists are describing a new, highly accurate non-animal test for these skin-sensitizers. Their study appears in ACS' journal Chemical Research in Toxicology.

Bruno Miguel Neves and colleagues explain that concerns about the ethics and costs of animal-based tests for skin sensitizers, plus regulations in the European Union, are fostering a search for alternative tests. Testing product ingredients prior to marketing is important, because allergic contact dermatitis is the most prevalent form of immunotoxicity in humans.

The scientists describe development of a cell-based alternative test that enlists genes and signaling pathways in mouse skin cells growing in the laboratory. Exposure to skin sensitizers triggers characteristic responses, activating genes and making cells release substances that communicate with adjacent cells. Evaluation of the test on 18 compounds showed that it had a sensitivity of 92 percent in correctly identifying actual sensitizers. It had a specificity of 100 percent and did not produce any false positive results — indicating that a substance caused sensitization when, in fact, it did not. The approach could be "extremely valuable" in revealing the interaction of skin cells with sensitizers, the scientists say.

Facts, background information, dossiers
More about American Chemical Society
  • News

    Shining a light on damage within polymers

    When it comes to even the most advanced materials, the adage "if it does not bend, it breaks" is often true. But before that final snap, most materials experience microscopic damage that could be fixed -- but only if you know it's there. In a study researchers introduce a new technique that ... more

    Making nail polish while powering fuel cells

    Hydrogen is widely regarded as a promising and clean alternative energy source. The traditional source of hydrogen (H2) for fuel cell use is water, which is split into H2 and oxygen (O2). But O2 is a low-value product. So, this week in ACS Central Science, researchers report a new approach ... more

    Using espresso machines to do chemistry

    Many chemists are familiar with taking trips to the espresso machine while running late-night experiments, but until now these excursions were merely undertaken for the caffeine boost. A group recently reported however, that espresso machines can quickly and inexpensively perform some compl ... more

  • Videos

    The World's Most Unavoidable Carcinogen

    Out in the open air on a beautiful summer day, most people don’t realize that they’re bathing in the world's most common carcinogen – the sun's rays. Ultra violet (UV) rays to be exact. Let’s take a look at how UV rays affect your body, and the sorts of built-in chemical defense systems you ... more

    Ice Cream Chemistry

    You're probably craving ice cream to cool you down this summer. Reactions looks at the chemistry involved in making the treat creamy and sweet. more

    Fluorescence Is Awesome (Here Is How It Works)

    Have you ever wondered about what makes a fluorescent color stand out so brightly from the rest? Today we’re digging into what makes them pop, and we’re going highlight some of the brilliant applications of fluorescence coming out of nanotechnology. more

  • Events
    Conference
    22-08 – 26-08
    2021
    Boston, US

    262nd ACS National Meeting & Exposition

    The American Chemical Society conference 262nd ACS National Meeting & Exposition will take place in Boston, US from 2021-08-22 to 2021-08-26. more

    Conference
    21-03 – 25-03
    2021
    San Antonio, US

    261st ACS National Meeting & Exposition

    The American Chemical Society conference 261st ACS National Meeting & Exposition will take place in San Antonio, US from 2021-03-21 to 2021-03-25. more

    Conference
    23-08 – 27-08
    2020
    San Francisco, US

    260th ACS National Meeting & Exposition

    The American Chemical Society conference 260th ACS National Meeting & Exposition will take place in San Francisco, US from 2020-08-23 to 2020-08-27. more

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE