My watch list
my.chemeurope.com  
Login  

Moving the MRI goalposts

28-11-2013: Scientists in the UK have developed a new class of MRI (magnetic resonance imaging) agents that promise to deliver clearer images more quickly.

Chemical shifts from proton NMR normally fall between 0-12ppm, but water and fat resonate at 4.7 and 1.3ppm respectively, causing noise that can overlap with MRI probe signals.

Now, David Parker and his team at the University of Durham have developed new probes, comprised of lanthanide complexes containing a t-butyl group, that shift the spectral window of MRI scans well away from these interfering signals. Parker describes this concept as “moving the goalposts.”

He said: “In any NMR experiment you are chasing sensitivity. We have enhanced the intrinsic ability to observe an MRI probe signal by a factor of 20.”

The distance between the lanthanide and the t-butyl group in the probes is fixed to optimise the rate of decay of the t-butyl signal, as well as its chemical shift. Using the new probes, the researchers were able to acquire data just a few minutes after administering them. They showed that the signal from the lanthanide-induced relaxation of the nine protons in the t-butyl group was shifted by up to 80ppm.

Parker says the new probes could lead to the development of new imaging experiments where the probes can be localised for defined periods of time in particular regions of the body.

 

Original publication:
P Harvey et al, Chem. Sci., 2013

Facts, background information, dossiers
  • Durham University
More about Durham University
  • News

    Solar activity playing a minimal role in global warming

    Changes in solar activity have contributed no more than 10 per cent to global warming in the twentieth century, a new study has found. The findings, made by Professor Terry Sloan at the University of Lancaster and Professor Sir Arnold Wolfendale at the University of Durham, find that neithe ... more

    Public must be involved in nanotech policy debate demands groundbreaking

    Decision-making on science – especially emerging technologies such as nanotechnology – must become more democratic, a new report on science policy argues. The group of leading European academics behind the 'Reconfiguring Responsibility' report argue forcefully that current governance activi ... more

More about Royal Society of Chemistry
  • News

    New coating is self-defence for seeds

    Scientists in Switzerland have developed a protective coating for seeds that poisons pests with cyanide when they bite into it. The coating is a system of two layers and only becomes toxic when the layers are mixed, eliminating the problem of environmental contamination that is associated w ... more

    Using bacteria to make electrodes

    Scientists in France have produced hematite using a bacterial pathway for use as an electrode material in Li-ion technologies. Currently, most commercial electrode materials for Li-ion technologies are prepared using the ceramic method, which requires long heating periods at high temperatur ... more

    Marine plant replacement for platinum in solar cells

    An international research team has shown that that the power conversion efficiency of sea tangle extract is comparable to platinum in solar cell electrodes. Dye-sensitized solar cells (DSCs) are quickly becoming a widespread and affordable alternative to photovoltaic solar cells. The electr ... more

  • Events

    Chemistry in the Oil Industry XlV Chemistry: Challenges and Responsibilities

    Focus is on Unconventional Resources & New Chemistry to enhance the profitability of new fields or to extend the economic life of mature wells. Must be done safely whilst protecting the environment. more

    Single-Molecule Microscopy and Spectroscopy

    Since their inception, optical detection and spectroscopy of single molecules have steadily expanded to an amazing variety of disciplines in natural sciences. Domains as varied as optical microscopy, quantum optics, nanophotonics, material science and soft-matter physical chemistry all have ... more

    Carbon Dioxide Utilisation

    Carbon dioxide utilisation processes convert CO2 into commercially viable products such as chemicals, polymers, building materials and fuels. Carbon dioxide utilisation is an emerging technology which can contribute to the reduction of greenhouse gas emissions by the use of CO2 to manufactu ... more

  • Companies

    Royal Society of Chemistry (RSC)

    The RSC is a leading international publisher of highly regarded journals and books in the chemical sciences. The RSC is also the professional body for chemists with a global membership of over 46,000. more

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE