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TSRI chemists achieve new technique with profound implications for drug development

Method expands options for making pure batches of 'one-handed' molecules


Breaking carbon-hydrogen (C-H) bonds to alter existing molecules to create new ones is an increasingly important avenue for drug development. Of particular interest is mirror-image or "one-handed" compounds, but C-H breaking methods for making pure batches of these molecules have worked with only ...


Animal testing methods for endocrine disruptors should change, team argues

Review suggests that oral gavage, the accepted method of dosing lab animals to test chemical toxicity, does not accurately mimic how humans are exposed to chemicals in everyday life


Challenging risk assessment methods used for decades by toxicologists, a new review of the literature led by environmental health scientist Laura Vandenberg at the University of Massachusetts Amherst suggests that oral gavage, the most widely accepted method of dosing lab animals to test chemical ...


Making better medicines with a handful of chemical building blocks


Soon, making and improving medical drugs could be as easy for chemists as stacking blocks is for a child. University of Illinois chemist Martin Burke, a pioneer of a technique that constructs complex molecules from simple chemical "building blocks," led a group that found that thousands of ...


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Secrets of enzyme used to make popular anti-cholesterol drug


In pharmaceutical production, identifying enzyme catalysts that help improve the speed and efficiency of the process can be a major boon. Figuring out exactly why a particular enzyme works so well is an altogether different quest. Take the cholesterol-lowering drug simvastatin. First marketed ...


Breakthrough harnesses light for controlled chemical reaction

Dual-catalyst technique controls 'handedness' of product


When chemist Tehshik Yoon looks out his office window, he sees a source of energy to drive chemical reactions. Plants "learned" to synthesize chemicals with sunlight eons ago; Yoon came to the field a bit more recently. In the journal Science, he and three collaborators detail a way to use ...


Tiny particles could help verify goods


Some 2 to 5 percent of all international trade involves counterfeit goods, according to a 2013 United Nations report. These illicit products — which include electronics, automotive and aircraft parts, pharmaceuticals, and food — can pose safety risks and cost governments and private companies ...


A better way to make unnatural amino acids

The findings have potential applications in cancer, infectious disease, Alzheimer's drugs


Chemists at The Scripps Research Institute (TSRI) have devised a greatly improved technique for making amino acids not found in nature. These "unnatural" amino acids traditionally have been very difficult to synthesize, but are sought after by the pharmaceutical industry for their potential ...


Building new drugs just got easier


Scientists at The Scripps Research Institute (TSRI) have developed a method for modifying organic molecules that significantly expands the possibilities for developing new pharmaceuticals and improving old ones. "This is a technology that can be applied directly to many medicinally relevant ...


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Pond-dwelling powerhouse's genome points to its biofuel potential


Duckweed is a tiny floating plant that's been known to drive people daffy. It's one of the smallest and fastest-growing flowering plants that often becomes a hard-to-control weed in ponds and small lakes. But it's also been exploited to clean contaminated water and as a source to produce ...


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Swiss cheese crystal, or high-tech sponge?


The sponges of the future will do more than clean house. Picture this, for example: Doctors use a tiny sponge to soak up a drug and deliver it directly to a tumor. Chemists at a manufacturing plant use another to trap and store unwanted gases. These technologies are what University at Buffalo ...


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