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New particle can track chemo

18-Jan-2016

Tracking the path of chemotherapy drugs in real time and at a cellular level could revolutionize cancer care and help doctors sort out why two patients might respond differently to the same treatment. Researchers at The Ohio State University have found a way to light up a common cancer drug so ...

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Catalyst combining reactivity and selectivity could speed drug development

19-Oct-2015

Chemists have long believed that inserting nitrogen into a carbon-hydrogen bond requires a trade-off between catalyst reactivity and selectivity. But a new manganese-based catalyst developed by University of Illinois chemists has given researchers both in one efficient, lower-cost ...

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TSRI chemists achieve new technique with profound implications for drug development

Method expands options for making pure batches of 'one-handed' molecules

27-Oct-2014

Breaking carbon-hydrogen (C-H) bonds to alter existing molecules to create new ones is an increasingly important avenue for drug development. Of particular interest is mirror-image or "one-handed" compounds, but C-H breaking methods for making pure batches of these molecules have worked with only ...

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Animal testing methods for endocrine disruptors should change, team argues

Review suggests that oral gavage, the accepted method of dosing lab animals to test chemical toxicity, does not accurately mimic how humans are exposed to chemicals in everyday life

30-Jun-2014

Challenging risk assessment methods used for decades by toxicologists, a new review of the literature led by environmental health scientist Laura Vandenberg at the University of Massachusetts Amherst suggests that oral gavage, the most widely accepted method of dosing lab animals to test chemical ...

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Making better medicines with a handful of chemical building blocks

21-May-2014

Soon, making and improving medical drugs could be as easy for chemists as stacking blocks is for a child. University of Illinois chemist Martin Burke, a pioneer of a technique that constructs complex molecules from simple chemical "building blocks," led a group that found that thousands of ...

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Secrets of enzyme used to make popular anti-cholesterol drug

15-May-2014

In pharmaceutical production, identifying enzyme catalysts that help improve the speed and efficiency of the process can be a major boon. Figuring out exactly why a particular enzyme works so well is an altogether different quest. Take the cholesterol-lowering drug simvastatin. First marketed ...

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Breakthrough harnesses light for controlled chemical reaction

Dual-catalyst technique controls 'handedness' of product

28-Apr-2014

When chemist Tehshik Yoon looks out his office window, he sees a source of energy to drive chemical reactions. Plants "learned" to synthesize chemicals with sunlight eons ago; Yoon came to the field a bit more recently. In the journal Science, he and three collaborators detail a way to use ...

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Tiny particles could help verify goods

15-Apr-2014

Some 2 to 5 percent of all international trade involves counterfeit goods, according to a 2013 United Nations report. These illicit products — which include electronics, automotive and aircraft parts, pharmaceuticals, and food — can pose safety risks and cost governments and private companies ...

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A better way to make unnatural amino acids

The findings have potential applications in cancer, infectious disease, Alzheimer's drugs

17-Mar-2014

Chemists at The Scripps Research Institute (TSRI) have devised a greatly improved technique for making amino acids not found in nature. These "unnatural" amino acids traditionally have been very difficult to synthesize, but are sought after by the pharmaceutical industry for their potential ...

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Building new drugs just got easier

14-Mar-2014

Scientists at The Scripps Research Institute (TSRI) have developed a method for modifying organic molecules that significantly expands the possibilities for developing new pharmaceuticals and improving old ones. "This is a technology that can be applied directly to many medicinally relevant ...

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