Oligonucleotides

News Oligonucleotides

• Luminous bacterial proteins detect chemicals in water
  

  While residual medications don’t belong in the water, trace metals from industrial process waters handled by the recycling industry are, in contrast, valuable resources. Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) have developed a simple color sensor principle which facilitates the more

• Professor Hagan Bayley named Chemistry World Entrepreneur of the Year 2008

  Professor Hagan Bayley, Professor of Chemical Biology at the University of Oxford, was named Entrepreneur of the Year by the Royal Society of Chemistry. The award recognises Professor Bayley’s excellence in science and contribution to British industry. He is the founder of Oxford Nanopore Technolog more

• Sigma-Genosys Enters Agreement With Novatia

  Sigma-Genosys, a division of Sigma-Aldrich has incorporated into its quality control (QC) lab an LC-MS system from Novatia. The system improves the molecular weight determination of larger synthetic oligonucleotides (>50 bases) as well as synthetic peptides. Novatia specializes in developing an inte more

White papers Oligonucleotides

• Application of the Amplifluor® SNPs Genotyping System using a FLUOstar OPTIMA microplate reader
  

  The detection of SNPs (single nucleotide polymorphisms) is an important tool for researchers in order to find mutations in DNA sequences. In this application note we describe a homogeneous fluorescence assay based on PCR. The Amplifluor® SNPs HT Genotyping System from Millipore was used to screen a number of samples with the help of the FLUOstar OPTIMA multidetection microplate reader from BMG LABTECH more

Publications Oligonucleotides

• Synthesis of Triazole-Linked Oligonucleotides with High Affinity to DNA Complements and an Analysis of Their Compatibility with Biosystems

  New oligonucleotide analogues with triazole internucleotide linkages were synthesized, and their hybridization properties were studied. The analogues demonstrated DNA binding affinities similar to those of unmodified oligonucleotides. The modification was shown to protect the oligonucleotides from n more

• IJMS, Vol. 14, Pages 11942-11962: Enhanced Inhibition of Prostate Tumor Growth by Dual Targeting the Androgen Receptor and the Regulatory Subunit Type Iα of Protein Kinase A in ...

  Progression to castration resistance is a major problem in the treatment of advanced prostate cancer and is likely to be driven by activation of several molecular pathways, including androgen receptor (AR) and cyclic AMP-dependent protein kinase A (PKA). In this study, we examined the therapeutic ef more

• Voltammetric behaviour of free DNA bases, methylcytosine and oligonucleotides at disposable screen printed graphite electrode platforms

  Improvements in analytical methods for the determination and quantification of methylcytosine in DNA are vital since it has the potential to be used as a biomarker to detect different diseases in the first stage as carcinomas and sterility. In this work we utilized screen printed graphite electrodes more

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