Pharmacology

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High Capacity Biological Sample Concentrator

For laboratories looking to concentrate larger numbers of biological samples presented in a range of different formats the miVac Quattro from Genevac is the perfect high capacity sample concentrator more

The fastest Triple Quadrupole Mass Spectrometer - Unparalleled detection speed for UHPLC systems

The LCMS-8030 combines the power of triple quadrupole mass spectrometry with unmatched speed to provide the ideal complement to its UHPLC systems. more

Catalogues Pharmacology

Problems in finding the right GC-Column for your application?

SGE offers a comprehensive range of GC capillary columns for almost any chromatographic application providing the best possible combination of Performance more

Services Pharmacology

ADME-Tox Studies Benefit from Advances in Evaporative Sample Preparation

A new web page from Genevac brings together the latest technological innovations, applications advances and links to references that details how new more

Videos Pharmacology

The fastest Triple Quadrupole Mass Spectrometer - Unparalleled detection speed for UHPLC systems

Shimadzu, one of the worldwide leading manufacturers in analytical instrumentation, has introduced the LCMS-8030 which combines the power of triple quadrupole mass spectrometry with unmatched speed to provide the ideal complement to its UHPLC systems. It is an efficient tool to increase lab efficien more

News Pharmacology

• Royal Society of Chemistry welcomes non-animal test that could spare one million mice worldwide

  The Royal Society of Chemistry welcomed the implementation of newly-developed non-animal methods of testing for poisons in shellfish from the seas around Britain which has led to 14,000 mice being spared testing and death in 2012.  If the techniques were to be adopted worldwide it could  save a mill more

• Super-strong, high-tech material found to be toxic to aquatic animals

  Carbon nanotubes (CNTs) are some of the strongest materials on Earth and are used to strengthen composite materials, such as those used in high-performance tennis rackets. CNTs have potential uses in everything from medicine to electronics to construction. However, CNTs are not without risks. A join more

• Risk re-classified for carcinogenic everyday substance: X-ray expert "decodes" diesel soot

  Since June 2012, it is official: The World Health Organisation (WHO) has classified diesel soot as a lung carcinogen. Artur Braun, a physicist at Empa and an X-ray spectroscopy expert, has made crucial contributions to analyzing the structure and composition of soot particles. Soot particles are dan more

White papers Pharmacology

• DKSH Performance Materials: Introduction of new program to source products
  

  Even under pressure to reduce costs, effective cooperation and hard work will always find a way to fulfill expectations. Most global players in the pharmaceutical industry are facing dramatic changes: blockbuster products launched in the 1990s will lose their patents over the next few years and face competition which will threaten their steady earnings more

• Application of the Amplifluor® SNPs Genotyping System using a FLUOstar OPTIMA microplate reader
  

  The detection of SNPs (single nucleotide polymorphisms) is an important tool for researchers in order to find mutations in DNA sequences. In this application note we describe a homogeneous fluorescence assay based on PCR. The Amplifluor® SNPs HT Genotyping System from Millipore was used to screen a number of samples with the help of the FLUOstar OPTIMA multidetection microplate reader from BMG LABTECH more

Publications Pharmacology

• Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 [Pharmacology]

  Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is extremely prevalent in pediatric malignant rhabdoid tumors (MRTs) or atypical teratoid rhabdoid tumors. This alteration is hypothesized to confer oncogenic dependency on EZH2 in these cancers. We report the discovery of a more

• TRPM8 activation attenuates inflammatory responses in mouse models of colitis [Pharmacology]

  Transient Receptor Potential Melastatin–8 (TRPM8), a recently identified member of the transient receptor potential (TRP) family of ion channels, is activated by mild cooling and by chemical compounds such as the supercooling agent, icilin. Since cooling, possibly involving TRPM8 stimulation, dimini more

• Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

  Historically, the most successful molecular target for antimalarial drugs has been heme biomineralization within the malarial parasite digestive vacuole. Heme released from catabolized host red blood cell hemoglobin is toxic, so malarial parasites crystallize heme to nontoxic hemozoin. For years it more

Websites Pharmacology