False negatives are recorded in every chemical detection system, but when animals are used as a scent detector, some false negatives can arise as a result of a failure in the link between detection and the trained alert response, or a failure of the handler to identify the positive alert. A ... more
The sense of taste is essential for identifying potential nutrients and poisons. Accordingly, specialized taste receptor cells are activated by food-derived chemicals. Because of its importance in the human diet, oral detection of starch, or its degradation products, would presumably be hig ... more
Thousands of odors are sensed and discriminated by G protein-coupled odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs). G protein-coupled receptor kinases (GRKs) may have a role in desensitization of ORs. However, whether ORs are susceptible to agonist-dependent desensit ... more
Nature Protocols 9, 2555 (2014).
Authors: Abhishek Kumar, Yicong Wu, Ryan Christensen, Panagiotis Chandris, William Gandler, Evan McCreedy, Alexandra Bokinsky, Daniel A Colón-Ramos, Zhirong Bao, Matthew McAuliffe, Gary Rondeau & Hari Shroff
We d ... more
Non-transferrin-bound iron (NTBI) emerges in plasma of patients with systemic iron overload, but has also been documented in further pathological conditions. Quantification of NTBI can be useful for diagnosis and management of these disorders. However, currently available detection methods ... more