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The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes. This unique family of E3 ligases includes parkin, whose dysfunction is linked to the pathogenesis of early-onset Parki ... more
Precise homoeostasis of the intracellular concentration of Cl− is achieved via the co-ordinated activities of the Cl− influx and efflux. We demonstrate that the WNK (WNK lysine-deficient protein kinase)-activated SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-respon ... more
Salmonella enterica is an opportunistic pathogen that produces a [NiFe]-hydrogenase under aerobic conditions. In the present study, genetic engineering approaches were used to facilitate isolation of this enzyme, termed Hyd-5. The crystal structure was determined to a resolution of 3.2 Å a ... more
TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] protein is known for its ability to inhibit glycolysis, shifting glucose consumption towards the pentose phosphate pathway to promote antioxidant protection of cancer cells. According to sequence homology and activ ... more
The extensive set of NMR doublings exhibited by the immunophilin FKBP12 (FK506-binding protein 12) arose from a slow transition to the cis-peptide configuration at Gly89 near the tip of the 80′s loop, the site for numerous protein-recognition interactions for both FKBP12 and other FKBP dom ... more
A facile microfluidic approach to prepare chitosan/silica core-shell hybrid microspheres with different pore structures has been developed. The hybrid microspheres show good performance in mechanics and adsorption and are outstanding and green catalyst support. In the optimum condition, the ... more
Polyaniline boronic acid (PABA) functionalized single walled carbon nanotube (SWNT) non enzymatic sensor was developed for detection of saccharides. The work involved electrochemical polymerization of 3-amino phenyl boronic acid (APBA) in presence of fluoride on the surface of SWNTs and the ... more
A novel vertically aligned carbon nanotube/graphene oxide (VACNT-GO) electrode is proposed, and its ability to determine atorvastatin calcium (ATOR) in pharmaceutical and biological samples by differential pulse adsorptive stripping voltammetry (DPAdSV) is evaluated. VACNT films were prepar ... more
A fluorescent detection method for glycoproteins in SDS-PAGE by using 4H-[1]-Benzopyrano[4,3-b]thiophene-2-carboxylic acid hydrazide (BH) was developed in this study. As low as 4-8 ng glycoproteins (transferrin, α1-acid glycoprotein) could be specifically detected by BH staining method, whi ... more
A state-of-art, highly sensitive sector-field inductively-coupled plasma mass spectrometer (SF-ICP-MS) was evaluated for analyzing fluid inclusions in combination with a 193 nm Excimer laser ablation, with the aim of expanding the technique to smaller inclusions and/or lower element concent ... more
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes. This unique family of E3 ligases includes parkin, whose dysfunction is linked to the pathogenesis of early-onset Parki ... more
Precise homoeostasis of the intracellular concentration of Cl− is achieved via the co-ordinated activities of the Cl− influx and efflux. We demonstrate that the WNK (WNK lysine-deficient protein kinase)-activated SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-respon ... more
Salmonella enterica is an opportunistic pathogen that produces a [NiFe]-hydrogenase under aerobic conditions. In the present study, genetic engineering approaches were used to facilitate isolation of this enzyme, termed Hyd-5. The crystal structure was determined to a resolution of 3.2 Å a ... more
TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] protein is known for its ability to inhibit glycolysis, shifting glucose consumption towards the pentose phosphate pathway to promote antioxidant protection of cancer cells. According to sequence homology and activ ... more
The extensive set of NMR doublings exhibited by the immunophilin FKBP12 (FK506-binding protein 12) arose from a slow transition to the cis-peptide configuration at Gly89 near the tip of the 80′s loop, the site for numerous protein-recognition interactions for both FKBP12 and other FKBP dom ... more
Inside the USCAP Journals Laboratory Investigation 94, 250 (March 2014). doi:10.1038/labinvest.2014.9 more
Bone and Soft Tissue Pathology Laboratory Investigation 94, 11 (February 2014). doi:10.1038/labinvest.2014.15 more
Infectious Disease Pathology Laboratory Investigation 94, 390 (February 2014). doi:10.1038/labinvest.2014.27 more
Hematopathology Laboratory Investigation 94, 332 (February 2014). doi:10.1038/labinvest.2014.26 more
Kidney/Renal Pathology Laboratory Investigation 94, 405 (February 2014). doi:10.1038/labinvest.2014.29 more
After wide spread coral bleaching in the Torres Strait in 2009-10 a monitoring program was established under the National Environmental Research Program and run by the Torres Strait Regional Authority to identify ocean conditions that may lead to future bleaching. One component of this prog ... more
Investigation of radionuclides (232Th and 238U) and trace elements (Cr, As and Pb) in soil from two legacy NORM (former mining sites) and one undisturbed naturally 232Th-rich site was conducted as a part of the ongoing environmental impact assessment in the Fen Complex area (Norway). The ma ... more
To study the effect of nitrate (NO3–) on selenate (SeO42–) reduction, we tested a H2-based biofilm with a range of influent NO3– loadings. When SeO42– was the only electron acceptor (stage 1), 40% of the influent SeO42– was reduced to insoluble elemental selenium (Se0). SeO42– reduction was ... more
In this study of autoimmunity among a population of Gullah African Americans in South Carolina, the links between environmental exposures and autoimmunity (presence of antinuclear antibodies (ANA)) have been assessed. The study population included patients with systemic lupus erythematosus ... more
There is a lack of comparable health-related quality of life (HRQoL) and utility data across all mental disorders and all inpatient and outpatient settings. Our objective was to investigate the HRQoL and utility scores of people with mental disorders in France, treated in outpatient and inp ... more
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