4-Aminosalicylic acid (4ASA) a non steroid anti inflammatory drug (NSAID) has been used for over 40 years in the treatment of inflammatory bowel diseases (IBDs). It is therefore an importance to assess physicochemical properties such as solubility and stability. The effect of cyclodextrins on the solubility and chemical stability of 4ASA was investigated. Inclusion complexes of 4ASA were characterized by the solubility method, differential scanning calorimetry (DSC) and Fourier transformer infrared spectroscopy (FT-IR). In addition, the influence of presence of CDs on stability was assessed at room temperature in different pH conditions. Complexation with CDs increased 4ASA aqueous solubility. The stoichiometric ratios of the inclusion complexes were 1:1 for α, β, γ and HP- CDs, respectively. Complexation with γ and HP-CDs has increased the 4ASA stability 4 fold. These observations suggest that 4ASA/CD complexes may be an attractive and practical procedure to modify drug physicochemical properties for use in delivery systems.
Plant parasitic nematodes are the most destructive group of plant pathogens worldwide and their control is extremely challenging. Plant Essential oils (EOs) and their constituents have a great potential in nematode control since they can be developed for use as nematicides themselves or can ... more
For over a century, ulcer has been a major cause of morbidity and mortality. Its treatment has progressed from vagotomy to proton pump inhibitors. However, the drugs used produce many adverse effects and are less effective than they ought to be. Therefore, there is a growing interest in alt ... more
Endophytic fungi are ubiquitous organisms found in the plants, residing intercellular or intracellular, at least for a portion of their lives without causing apparent symptoms of infection. Almost all plants are known to harbor endophytes. The choice of the plant to be used for exploring en ... more
Physicists describe how they have synthesized a new material that belongs to the iron-selenide class of superconductors, called LixFe2Se2(NH3)y, in a paper about to be published in EPJ B. The work was carried out by Ernst-Wilhelm Scheidt from the University of Augsburg and colleagues. This ... more
The U.S. federal government is significantly underestimating the costs of carbon pollution because it is using a faulty analytical model, according to a new study published in the Journal of Environmental Studies and Sciences. A more appropriate accounting of costs would pave the way to cle ... more
Springer advisory board member Vladimir V. Dmitriev, along with fellow scientists Yuriy M. Bunkov and Igor A. Fomin, have been named winners of the 2008 Fritz London Memorial Prize for their discovery and understanding of the "Phase Coherent Spin Precession and Spin Superfluidity of 3He-B." ... more