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Overcoming the “Oxidant Problem”: Strategies to Use O2 as the Oxidant in Organometallic C–H Oxidation Reactions Catalyzed by Pd (and Cu)

Oxidation reactions are key transformations in organic chemistry because they can increase chemical complexity and incorporate heteroatom substituents into carbon-based molecules. This principle is manifested in the conversion of petrochemical feedstocks into commodity chemicals and in the synthesis of fine chemicals, pharmaceuticals, and other complex organic molecules. The utility and function of these molecules correlate directly with the presence and specific placement of oxygen and nitrogen heteroatoms and other functional groups within the molecules.Methods for selective oxidation of C–H bonds have expanded significantly over the past decade, and their role in the synthesis of organic chemicals will continue to increase. Our group’s contributions to this field are linked to our broader interest in the development and mechanistic understanding of aerobic oxidation reactions. Molecular oxygen (O2) is the ideal oxidant. Its low cost and lack of toxic byproducts make it a highly appealing reagent that c...

Authors:   Alison N. Campbell; Shannon S. Stahl
Journal:   Accounts of Chemical Research
Year:   2012
DOI:   10.1021/ar2002045
Publication date:   23-Jan-2012
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