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Multistage character of adsorption isotherms of human and bovine serum albumins on hydroxyapatite nanoparticles from aqueous solution have been developed by the radionuclide-microscopy method. Such a character of isotherms indicated the number of physicalchemical processes: formation of the peptide-nanohydroxyapatite complex and following by aggregation in liquid and solid phases. This hypothesis was confirmed by X-ray and dynamic light-scattering analysis, It was shown, that when hydroxyapatite is formed in albumin solution the peptide-nanohydroxyapatite complex formation is followed by morphology and structure exchange of hydroxyapatite nanocrystals.
| Authors: | A. V. Severin, G. A. Badun, M. G. Chernysheva | |
| Journal: | Moscow University Chemistry Bulletin | |
| Year: | 2012 | |
| DOI: | 10.3103/S0027131411060083 | |
| Publication date: | 07-02-2012 |
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