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Privileged structures like Benzothiazole and Pyrrolobenzodiazepine offer wonderful opportunity to explore in anti-cancer drug discovery as a mean to counter drug-resistance problem. BT-PBD hybrids and diverse BT derivatives have been synthesized and their in vitro cytotoxic activities were screened against five cancer cell lines have been discussed. The novel compounds showed promising results as compared with the marketed drug etoposide and could well be used in future anti-cancer drug development studies.
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| Authors: | D. Subhas Bose, Mohd. Idrees, Ismail K. Todewale, N.M. Jakka, J. Venkateswara Rao | |
| Journal: | European Journal of Medicinal Chemistry | |
| Year: | 2012 | |
| DOI: | 10.1016/j.ejmech.2012.01.014 | |
| Publication date: | 23-04-2012 |
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