Synthetic Methods for the Hydrodehalogenation of Halogenated Heterocycles
This review provides an overview of methods that lead to the substitution of halogens from rings of halogenated heterocycles by hydrogen. The first part of the review treats the subject matter from the viewpoint of the method used for the hydrodehalogenation reaction, while ... more
Drug Repurposing in Chemical Genomics: Can We Learn from the Past to Improve the Future?
More needs to be done by the private sector to optimize the drug discovery and development pipeline. In addition, significant efforts should also be focused on the understanding of mechanism of diseases, on the characterization of unexplored biochemical pathways and on the ... more
New Insights in Protein Kinase Conformational Dynamics
A significant portion of recent drug development efforts has been focused on protein kinases. More than a hundred different compounds are currently under clinical trials and nearly 30% of all the scientific articles in drug discovery are on protein kinase inhibitors. Protei ... more