my.chemeurope.com
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
A series of new terphenyl benzimidazoles (3a–z and 3aa–ad) were synthesized and evaluated for their anticancer activity. All the 30 compounds have shown moderate to good anticancer potency, however some of the compounds (3j, 3m−t and 3aa−ad) exhibited prominent anticancer potency with GI50 values ranging from <0.1 to 9.72 μM. These compounds exhibit G2/M phase arrest and the analysis of tubulin by Western blot experiments in case of 3t and 3ad shows the disturbances that are caused in the ratio of soluble versus polymerized tubulin in cells. Compounds 3t and 3ad are the most promising candidates amongst the series and has the potential to be taken up for further detailed studies either alone or in combination with the existing therapies.
Graphical Abstract
Highlights
A library of terphenyl benzimidazole compounds were prepared and evaluated for anticancer activity. Further, some of the biological assays were also carried.
| Authors: | Ahmed Kamal, M. Kashi Reddy, Thokhir B. Shaik, Rajender, Y.V.V. Srikanth, V. Santhosh Reddy, G. Bharath Kumar, Shasi V. Kalivendi | |
| Journal: | European Journal of Medicinal Chemistry | |
| Year: | 2012 | |
| DOI: | 10.1016/j.ejmech.2012.01.004 | |
| Publication date: | 23-04-2012 |
Watchlist
This is where you can add this publication to your personal favourites.
Additional Information
Publication date: July 2013Source:Journal of Solid State Chemistry, Volume 203 Author(s): S. Kumar , K. Singh , M. Miclau , Ch. Simon , C. Martin , A. Maignan The change from antiferromagnetism induced ferroelectricity to spin glass ferroelectric relaxor has been studied along the ... more
Investigation of an unusual low-temperature phase transformation in RbBH4 by neutron diffraction
Publication date: July 2013Source:Journal of Solid State Chemistry, Volume 203 Author(s): Brian B. Kitchen , Nina Verdal , Terrence J. Udovic , John J. Rush , Michael R. Hartman , Daniel J. DeVries To investigate the previously reported low-temperature phase transition in rubidium ... more
Effect of co-doping Tm3+ ions on the emission properties of Dy3+ ions in tellurite glasses
Publication date: July 2013Source:Journal of Solid State Chemistry, Volume 203 Author(s): T. Sasikala , L. Rama Moorthy , A. Mohan Babu , T. Srinivasa Rao The present work reports the absorption, photoluminescence and decay properties of singly doped Dy3+ and co-doped Dy3+/Tm3+ ions ... more
Elsevier Acquires the Beilstein Database
Elsevier announced the acquisition through its subsidiary MDL Information Systems GmbH, of the Beilstein Database, the world's largest compilation of chemical facts and the premier database in the field of organic chemistry. Elsevier has been exclusively involved in both the production an ... more
Über CHEMIE.DE
CHEMIE.DE Information Service GmbH runs specialist scientific internet portals. The secret to our success? We are familiar with what we publish.
Advertising at CHEMIE.DE
Our advertising formats support you in getting your message across to a clearly defined target audience.
© 1997-2013 CHEMIE.DE Information Service GmbH, All rights reserved
Netmeeting
