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The synthesis and biological evaluation of three new cholestane frameworks of the type: (25R)-3β,16β-Diacetoxy-23-ethylidene-26-hydroxy-22-oxocholestane, starting from spirostanic sapogenins of the 25R series, is described. The compounds were obtained by the reductive cleavage of the F ring of 22-oxo-231,26-epoxycholestane derivatives using 9-BBN. These modified derivatives exhibit cytotoxic activity against CEM and MCF7 cells and are able to induce apoptosis in them. Its effect on the cell cycle was determined.
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| Authors: | José Oscar H. Pérez-Díaz, Lucie Rárová, J. Paul Muñoz Ocampo, Nancy E. Magaña-Vergara, Norberto Farfán, Miroslav Strnad, Rosa Santillan | |
| Journal: | European Journal of Medicinal Chemistry | |
| Year: | 2012 | |
| DOI: | 10.1016/j.ejmech.2012.02.020 | |
| Publication date: | 30-04-2012 |
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