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From the whole plant of Sarcandra glabra, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1), together with seven known compounds including eleutheroside B1 (2), 5-O-caffeoylshikimic acid (3), (–)-(7S, 8R)-dihydrodehydro-diconiferyl alcohol (4), (–)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol 9-, 9′- and 4-O-â-D-glucopyranoside (5–7), and (–)-(7S, 8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8) was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound 2 was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC50 value of 2.53 and 1.85 µM, respectively.
| Authors: | Wu, Haifeng ; Hu, Xiaoru ; Zhang, Xiaopo ; Chen, Shilin ; Yang, Junshan ; Xu, Xudong | |
| Journal: | Molecules | |
| Volume: | 17 | |
| Issue: | 5 | |
| Year: | 2012 | |
| Pages: | 5212 | |
| DOI: | 10.3390/molecules17055212 | |
| Publication date: | 04-05-2012 |
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