Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions

Intraprotein Formation of a Long Wavelength Absorbing Complex and Inhibition of Excited-State Deprotonation in a Chiral Hydroxybiphenyl

The two enantiomers of 2-(2-hydroxybiphenyl-4-yl)propanoic acid ((S)- and (R)-BPOH) have been selected as probes for human serum albumin (HSA). Photophysical characterization in the absence of protein led to emission maxima, singlet energies, quantum yields, and fluorescence lifetime values ... more

State-to-State Photodissociation Dynamics of H2O in the B-band: Competition between Two Coexisting Nonadiabatic Pathways

The photodissociation of H2O in its B band is a prototype for nonadiabatic reaction dynamics. In addition to dissociation via the adiabatic pathway to the OH(Ã2Σ+) + H fragments, it also produces the OH(X̃2Π) + H fragments through two nonadiabatic pathways: the B̃ → X̃ transition via two co ... more

Time-Resolved Fluoroimmunoassay as an Advantageous Analytical Method for Assessing the Total Concentration and Environmental Risk of Fluoroquinolones in Surface Waters

Due to the widespread occurrence in the environment and potential risk toward organisms of fluoroquinolones (FQs), it is of importance to develop high efficient methods for assessing their occurrence and environmental risk. A monoclonal antibody (Mab) with broad cross-reactivity to FQs was ... more

Rohm and Haas Powder Coatings Receives First Responsible Care Management System (RCMS) Site Certification

Rohm and Haas Powder Coatings is delighted to announce that its Reading, Pennsylvania, facility is the first site in the world to receive the RCMS® Site Certification awarded by the American Chemical Council (ACC). When Raj Gupta, Chairman and CEO of Rohm and Haas Company, became Chairman ... more

American Chemical Society Publications

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