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Recent studies have shown that cerebellar Bergmann glia display coordinated Ca2+ transients in live mice. However, the functional significance of Bergmann glial Ca2+ signaling remains poorly understood. Using transgenic mice that allow selective stimulation of glial cells, we report here that cytosolic Ca2+ regulates uptake of K+ by Bergmann glia, thus providing a powerful mechanism for control of Purkinje cell-membrane potential. The decline in extracellular K+ evoked by agonist-induced Ca2+ in Bergmann glia transiently increased spike activity of Purkinje cells in cerebellar slices as well as in live anesthetized mice. Thus, Bergmann glia play a previously unappreciated role in controlling the membrane potential and thereby the activity of adjacent Purkinje cells.
| Authors: | Fushun Wang; Qiwu Xu; Weishan Wang; Takahiro Takano; Maiken Nedergaard | |
| Journal: | Proceedings of the National Academy of Sciences current issue | |
| Volume: | 109 | |
| Issue: | 20 | |
| Year: | 2012 | |
| Pages: | 7911 | |
| DOI: | 10.1073/pnas.1120380109 | |
| Publication date: | 15-05-2012 |
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