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Eplerenone is an aldosterone receptor antagonist. Single crystals of the title compound [systematic name: 9α,11‐epoxy‐7α‐(methoxycarbonyl)‐3‐oxo‐17α‐pregn‐4‐ene‐21,17‐carbolactone dioxane solvate], C24H30O6·C4H8O2, were obtained from a dioxane solution. Within the eplerenone molecule, both five‐membered rings display an envelope conformation. The three six‐membered rings exhibit different conformations: chair, half‐chair and envelope. In the crystal structure, adjacent eplerenone molecules are linked together via weak intermolecular C—H...O hydrogen bonding, forming a cavity of about 310 Å3, and the dioxane solvent molecules occupy the cavity. The solvent molecule is disordered equally over two positions.
| Authors: | Xu, Lu‐Zhuang; Yang, Qian; Nie, Jing‐Jing | |
| Journal: | Acta Crystallographica Section E | |
| Volume: | 63 | |
| Issue: | 12 | |
| Year: | 2007 | |
| Pages: | o4898 | |
| DOI: | 10.1107/S1600536807060199 | |
| Publication date: | 01-12-2007 |
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